Лаборатория токсинологии и молекулярной систематики

Наира Айвазян

Заведующая лабораторией
Доктор биологических наук

эл-почта:taipan@ysu.am, nairaayvazyan@physiol.sci.am

Изучение структурно-функциональных изменений биологически активных белков из животных и растительных ядов представляет большой интерес для молекулярно-биологических исследований, а также для разработки новых лекарственных препаратов и свежих стратегических подходов для получения моно- и поливалентных сывороток антитоксического действия.

Данные токсикологические исследования на сегодня весьма актуальны и перспективны для Армении, как то: подробный биохимический анализ отдельных составляющих зоотоксинов, изучение их структуры и механизмов действия как в биохимическом, так и в фармакологическом и иммунологическом аспектах, а также изучение системы клеточных рецепторов, задействованных в распознавании отдельных компонентов яда и перспектив их применения в терапевтических целях (например, при некоторых нейродегенеративных и раковых патологиях).

Публикации
The development and evaluation of the efficacy of ovine derived experimental antivenom immunoserum against Macrovipera lebetina obtusa (MLO) venom. Kishmiryan, A., Ghukasyan G., Ghulikyan L., Darbinyan A., Parseghyan L., Voskanyan A., Ayvazyan N. //J Venom Res, 2021, Vol 11, 7-15 PMID: 33747434; PMCID: PMC7970454 Macrovipera lebetina obtusa Snake Venom as a Modulator of Antitumor Effect in S-180 Sarcoma Mouse Model. Mol Biol (2021), vol.55(3), Ghazaryan, N., Movsisyan, N., Macedo, J.C. et al. Comparison of the effects of dendrimer, micelle and silver nanoparticles on phospholipase A2 structure. Maria Terehova, Volha Dzmitruk, Viktar Abashkin, Gayane Kirakosyan, Gevorg Ghukasyan, Maria Bryszewska, Elzbieta Pedziwiatr-Werbicka, Maksim Ionov, Rafael Gómezd, F. Javierde la Mata, Serge Mignani, Xiangyang Shi, Jean-Pierre Majoral, Aleksandr Sukhodola, Dzmitry Shcharbin // Journal of Biotechnology, v. 331, 2021, pp 48-52. < A molecular dynamics study of protein denaturation induced by sulfonate-based surfactants. Poghosyan, A.H., Shahinyan, A.A., Kirakosyan, G.R., Ayvazyan N.M., Mamasakhlisov Y. S, Papoian G.A. // J Mol Model (2021), 27: 261. Multiple myeloma in Armenia during the period 2006–2018: facts and discussion. Ghazaryan, N., Danelyan, S., Bardakhchyan, S. et al. // BMC Cancer 21, 941 (2021) The Synergy of Membranotropic Effect of the Two Pla2 Fractions of Macrovipera lebetina obtusa Venom on the Model Membranes. Ghazaryan, N.A., Kishmiryan, A. & Ayvazyan, N.M.: J Membrane Biol, 2020, 253, 609-616. (https://doi.org/10.1007/s00232-020-00144-z The specificity of Middle East vipers' venom action on the nervous tissue. TOXICON Special Issue. Ayvazyan N., Kishmiryan A., Terzyan D., Voskanyan A.: 20th World Congress of the International Society on Toxinology, Buenos-Aires, Argentina, 8-13 Sep, 2020; Volume 177, Supplement 1, p. S11. Neurobiology and therapeutic utility of neurotoxins targeting postsynaptic mechanisms of neuromuscular transmission. Ayvazyan N O’Leary V Dolly J Ovsepian S. Drug Discovery Today 2019 \| The antitumor efficacy of monomeric disintegrin obtustatin in S-180 sarcoma mouse model Narine Ghazaryan, Naira Movsisyan, Joana Catarina Macedo, Sara Vaz, Naira Ayvazyan, Luis Pardo, Elsa Logarinho. Invest New Drugs (January 2019). https://doi.org/10.1007/s10637-019-00734-2 \| Neurobiology and therapeutic applications of neurotoxins targeting transmitter release. Saak V.Ovsepian, Valerie B.O’Leary, Naira M.Ayvazyan, Ahmed Al-Sabie Vasilis Ntziachristosab, James O.Dolly / Pharmacology & Therapeutics, August 2018 (available online) Anti-tumor effect investigation of obtustatin and crude Macrovipera lebetina obtusa venom in S-180 sarcoma bearing mice. N. Ghazaryan, L. Ghulikyan, A. Kishmiryan, G. Kirakosyan, O. Nazaryan, T. Ghevondyan, N. Zakaryan, and N. Ayvazyan // European Journal of Pharmacology, 2015, volume 764, pp. 340-345. Anti-tumor effect investigation of obtustatin and crude Macrovipera lebetina obtusa venom in S-180 sarcoma bearing mice. Ghazaryan N.A., Ghulikyan L.A., Kishmiryan A.V., Kirakosyan G.R., Nazaryan O.H., Ghevondyan T.H., Zakaryan N.A., Ayvazyan N.M. (2015) Eur J Pharmacol. 764: p.340-345. Phospholipases A2 from Viperidae snakes: Differences in membranotropic activity between enzymatically active toxin and its inactive isoforms. Ghazaryan N.A., Ghulikyan L., Kishmiryan A., Andreeva T.V., Utkin Y.N., Tsetlin V.I., Lomonte B., Ayvazyan N.M. (2015) Biochimica et Biophysica Acta (BBA) - Biomembranes, 1848 (2): p. 463-468. Comparative analysis of membranotropic properties of various phospholipases A2 from venom of snakes of the family viperidae. Kazaryan N. A., Gulikyan L., Lomonte B., Andreeva T. V., Tsetlin V. I., Utkin U. N., Aivazyan N. M. (2014) // Doklady Biochemistry and Biophysics, Volume 457, Issue 1, p. 125-127. Paraspecificity of Vipera a. ammodytes-specific antivenom towards Montivipera raddei and Macrovipera lebetina obtusa venoms. Kurtović T, Lang Balija M, Ayvazyan N, Halassy B.Toxicon. 2014 Feb;78:103-12. doi: 10.1016/j.toxicon.2013.12.004. Epub 2013 Dec 27. Lipid bilayer condition abnormalities following Macrovipera lebetina obtusa snake envenomation. Ayvazyan NM, Ghazaryan NA.Toxicon. 2012 Sep 15;60(4):607-13. doi: 10.1016/j.toxicon.2012.05.016. Epub 2012 May 31. Molecular events associated with Macrovipera lebetina obtusa and Montivipera raddei venom intoxication and condition of biomembranes. Ayvazyan NM, Zaqaryan NA, Ghazaryan NA.Biochim Biophys Acta. 2012 May;1818(5):1359-64. doi: 10.1016/j.bbamem.2012.02.001. Epub 2012 Morphological changes of proteolipid giant unilamellar vesicles affected by Macrovipera lebetina obtusa venom visualized with fluorescence microscope. Ghazaryan NA, Ghulikyan LA, Ayvazyan NM. J Membr Biol. 2013 Aug;246(8):627-32. doi: 10.1007/s00232-013-9576-1. Epub 2013 Jul 6. Snake venomics of the Armenian mountain vipers Macrovipera lebetina obtusa and Vipera raddei. Sanz L, Ayvazyan N, Calvete JJ. J Proteomics. 2008 Jul 21;71(2):198-209. doi: 10.1016/j.jprot.2008.05.003. Epub 2008 Jun 3.